DEAR MAYO CLINIC: I’ve heard of people being a living kidney donor for someone they don’t know who’s in need of a transplant. How does that work? Don’t you have to be a relative, or at least a friend, to donate a kidney?

If you’re interested in being a living kidney donor, it’s not necessary for you to be related to — or even to know — the person who receives your kidney.

This can be accomplished in several ways. The first is in a nondirected donation, where the donor does not name the organ recipient. The second is a paired donation, where two or more people who are in need of a transplant trade donors.

Your kidneys are two organs, each about the size of a fist, in the back of your abdomen on either side of your spine. Kidneys remove extra fluid and waste from your body, and help control blood pressure. When a person’s kidneys no longer work, a condition called “chronic kidney failure,” a kidney transplant usually is the best treatment option. A transplant often allows people to return to a fully active life.

In a nondirected donation, the transplant recipient is determined by medical compatibility and need. The donor and recipient may choose to learn one another’s identity, or they may wish to remain anonymous.

Another way people donate a kidney to someone they don’t know is through paired donation. Paired-organ donation may be an option when someone wants to donate a kidney — often to a relative or friend — but the kidney is not a good match for the intended recipient. In that case, a transplant center may make arrangements for two people who need donated kidneys to trade donors, so each gets an organ that is a good match.

A nondirected living donor also may participate in paired-organ donation to help match incompatible pairs. More than one pair of incompatible living donors and recipients may be linked with a nondirected living donor to form a donation chain to receive compatible organs. In this scenario, multiple recipients benefit from a single nondirected living donor.

Nondirected living organ donation and paired-organ donation have become increasingly important in recent years to meet a growing need.

If you are interested in becoming a kidney donor, contact a transplant center near you, or go online to the United Network for Organ Sharing at unos.org for more information. — Patrick Dean, M.D., Transplantation Surgery, Mayo Clinic, Rochester.

Mayo Clinic Q & A is an educational resource and doesn’t replace regular medical care. Email a question to MayoClinicQ&Amayo.edu. For more information, visit www.mayoclinic.org.

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